TRPA1 Function in Skeletal Muscle Sensory Neurons Following Femoral Artery Occlusion
نویسندگان
چکیده
منابع مشابه
Augmented P2X response and immunolabeling in dorsal root ganglion neurons innervating skeletal muscle following femoral artery occlusion.
The responsiveness of sensory neurons to muscle metabolites is altered under the conditions of insufficient limb blood supply in some diseases, such as peripheral artery disease. The purpose of this study was to examine ATP-induced current with activation of purinergic P2X subtypes P2X₃ and P2X₂/₃ in dorsal root ganglion (DRG) neurons of control limbs and limbs with 24 h of femoral artery occlu...
متن کاملP 2 X Response and Immunolabeling in Dorsal Root Ganglion Neurons 5 Innervating Skeletal Muscle Following Femoral Artery Occlusion
23 The responsiveness of sensory neurons to muscle metabolites is altered under the 24 conditions of insufficient limb blood supply in some diseases such as peripheral artery disease. 25 The purpose of this study was to examine ATP-induced current with activation of purinergic 26 P2X subtypes P2X 3 and P2X 2/3 in dorsal root ganglion (DRG) neurons of control limbs and 27 limbs with 24 hrs of fe...
متن کاملFemoral Artery Occlusion Increases Muscle Pressor Reflex and Expression of Hypoxia-Inducible Factor-1α in Sensory Neurons.
Hypoxia inducible factor-1 (HIF-1) has an important contribution to pathophysiological changes of homeostasis under conditions of oxygen deprivation as well as ischemia. We examined the effects of femoral artery occlusion on HIF-1α expression in sensory dorsal root ganglion (DRG) neurons of rats. Also, we examined cardiovascular responses to static muscle contraction following femoral occlusion...
متن کاملContribution of nerve growth factor to augmented TRPV1 responses of muscle sensory neurons by femoral artery occlusion.
In rats, hindlimb muscle ischemia induced by femoral artery occlusion augments the sympathetic nervous response to stimulation of transient receptor potential vanilloid type 1 (TRPV1) by injection of capsaicin into the arterial blood supply of the hindlimb muscles. The enhanced sympathetic response is due to alterations in TRPV1 receptor expression and its responsiveness in sensory neurons. The...
متن کاملTRPA1 modulates mechanotransduction in cutaneous sensory neurons.
Transient receptor potential ankyrin 1 (TRPA1) is expressed by nociceptive neurons of the dorsal root ganglia (DRGs) and trigeminal ganglia, but its roles in cold and mechanotransduction are controversial. To determine the contribution of TRPA1 to cold and mechanotransduction in cutaneous primary afferent terminals, we used the ex vivo skin-nerve preparation from Trpa1(+/+), Trpa1(+/-), and Trp...
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ژورنال
عنوان ژورنال: Cellular Physiology and Biochemistry
سال: 2017
ISSN: 1015-8987,1421-9778
DOI: 10.1159/000480003